He was the youngest student in his class, but the most knowledgeable. He obtained his primary certificate in 1910 ranking first nationwide. At the age of 16 he obtained his Baccalaureate in 1914 to become the youngest student at that time to be awarded such a certificate. He preferred to enroll in the Teachers' College rather than the Faculties of Medicine or Engineering due to his deep interest in mathematics.

He graduated in 1917. Due to his excellence in mathematics, the Egyptian Ministry of Education sent him to England where he obtained BSc (Honors) from the University of Nottingham, 1920.

He was the first Egyptian professor of applied mathematics in the Faculty of Science. He became dean of the faculty in 1936, at the age of 38. He remained in office as a dean of the Faculty of Science until he died in 1950.

Musharafa was interested in the history of science, especially in studying the contributions of Arab scientists in the Middle Ages. With his student M. Morsi Ahmad, he published al-Khwārizmī's book The Compendious Book on Calculation by Completion and Balancing (Kitab al-Jabr wa-l-Muqabala).

He died January 15, 1950. International Scientific circles have never been so deeply moved at the death of an Egyptian scientist as they were at the death of the Egyptian genius Dr. A.M. Mosharafa.